Protein Details: Potassium voltage-gated channel subfamily D member 3

Protein ID

ICDB_Pro_1668

Protein Name

Potassium voltage-gated channel subfamily D member 3

Gene Name

KCND3

Organism

Homo sapiens (Human)

Length

655 amino acids

AlphaFoldDB

AF-Q9UK17-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

Sequence

MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL

PDB Structures

1S1G 2NZ0 7W3Y 7W6N 7W6S 7W6T

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Spinocerebellar Ataxia 19 and Brugada Syndrome 9

Location

Highly expressed in heart and brain; in particular in cortex; cerebellum; amygdala and caudate nucleus (PubMed:10200233; PubMed:10729221; PubMed:9843794). Detected at lower levels in liver; skeletal muscle; kidney and pancreas (PubMed:10200233; PubMed:10729221).

DOI ID

10.1152/ajpheart.1998.275.6.h1963; 10.1152/jn.1999.81.4.1974; 10.1006/geno.2000.6117; 10.1038/nature04727; 10.1101/gr.2596504; 10.1016/s0014-5793(02)03296-9; 10.1161/circresaha.108.191007; 10.1016/j.hrthm.2011.02.021; 10.1002/humu.22058; 10.1016/s0896-6273(04)00049-2; 10.1038/nn1822; 10.1126/science.1133427; 10.1002/ana.23701; 10.1002/ana.23700; 10.1007/s12311-017-0883-4

RefSeq

NP_004971.2 [Q9UK17-1]; NP_751948.1 [Q9UK17-2]; XP_005270908.1; XP_006710692.1 [Q9UK17-1]; XP_006710693.1; XP_016856733.1 [Q9UK17-1]